Urodynamic and Clinical Effects of Terazosin Therapy in Patients with Symptomatic Benign Prostatic Hyperplasia

P u r p o s e ; W e e v a l u a t e d t h e u r o d y n a m i c a n d c l i n i c a l e f f e c t s o f t e r a z o s i n i n p a t i e n t s w i t h s y m p t o m a t i c b e n i g n p r o s t a t i c h y p e r p l a s i a ( B P H ) . M a t e r i a l s a n d M e t h o d s : A t o t a l o f 4 5 p a t i e n t s w h o p a r t i c i p a t e d i n a n m l t i c e n t e r t r i a l w a s e v a l u a t e d w i t h u r o d y n a m i c p r e s s u r e f l o w s t u d i e s b e f o r e a n d a f t e r 2 6 w e e k s o f t r e a t m e n t . R e s u l t s : M a x i m u m f l o w r a t e a n d s y m p t o m s c o r e i m p r o v e d s i g n i f i c a n t l y i n 2 2 p a t i e n t s w i t h a n d 1 1 w i t h o u t b l a d d e r o u t l e t o b s t r u c t i o n w h o c o m p l e t e d 2 6 w e e k s o f t r e a t m e n t . I n p a t i e n t s w i t h b l a d d e r o u t l e t o b s t r u c t i o n t h e c o n d i t i o n w a s s i g n i f i c a n t l y r e d u c e d a n d i n p a t i e n t s w i t h o u t o b s t r u c t i o n , s i g n i f i c a n t u r o d y n a m i c c h a n g e s c o u l d n o t b e d e t e c t e d . C o n c l u s i o n s : T e r a z o s i n t r e a t m e n t r e s u l t s i n s y m p t o m a t i c r e l i e f a n d i m p r o v e d u r i n a r y f l o w i n p a t i e n t s w i t h a n d w i t h o u t b l a d d e r o u t l e t o b s t r u c t i o n , a n d i n s i g n i f i c a n t i m p r o v e m e n t i n p a t i e n t s w i t h u r o d y n a m i c a l l y p r o v e d o b s t r u c t i o n .